Defining the zinc homeostasis mechanisms of Klebsiella pneumoniae and their role in host-pathogen interaction
This PhD project will be based at the University of Melbourne with an initial stay of 18-24 months at University of Toronto.
Klebsiella pneumoniae is a globally significant multi-drug resistant pathogen. Our recent studies investigating the chemical biology of this bacterium have identified numerous uncharacterised pathways involved in the acquisition of the essential metal zinc from the host.
This project will provide the first descriptions of these pathways and how they contribute to the growth, virulence and antibiotic resistance of K. pneumoniae. The outcomes of this study will provide information essential to exploiting nutrient dependency in breaking multi-drug resistance in K. pneumoniae and other Gram-negative bacteria.
A/Prof Christopher McDevitt (University of Melbourne)
A/Prof Trevor Moraes (University of Toronto)
How to Apply